AAV are adeno-associated viruses used in biotechnology for genome editing. AAV are a popular choice of viral vector for many applications, including gene therapies. Wild type AAV are well-studied reliable vectors and are the best candidates for gene therapies, especially in ophthalmology.
In vitro transduction
(including in the presence of antibodies)
Tropism testing in human retina explants
and pathological retina-like organoids
Biodistribution and in vivo tropism tests
on wild-type and disease model mice